RxLink CoEnzyme Q10 100mg

RxLink Co-Enzyme Q10
100 mg Softgels with Vitamin E
DESCRIPTION
RxLink Co-Enzyme Q10 softgels contain pure co-enzyme Q10
(ubiquinone). Co-enzyme Q10 is solubilized in a base of rice
bran oil and vitamin E to enhance absorption of co-enzyme
Q10.
FUNCTIONS
Co-Enzyme Q10 (ubiquinone) is an important rate limiting
cofactor in the mitochondrial electron transport chain, the
biochemical pathway in cellular respiration from which
adenosine triphosphate (ATP), the form of energy used by the
body, is derived. Since cellular activities are dependent upon
energy, co-enzyme Q10 is crucial for the efficient functioning
of nearly every cell. In addition to its well-established function
as a component of the mitochondrial electron transport chain,
co-enzyme Q10 has in recent years acquired increasing
attention regarding its antioxidant properties. RxLink Co-Enzyme Q10
occurs in all cellular membranes as well as in blood serum
and in serum lipoproteins. As a lipid-soluble antioxidant,
coenzyme Q10 efficiently protects membrane phospholipids
and serum low-density lipoproteins from lipid peroxidation.
And, as recent data indicate, it also protects mitochondrial
membrane proteins and DNA from free radical induced
oxidative damage.
These effects of co-enzyme Q10 are independent of those
of other antioxidants, such as vitamin E; although co
enzyme Q10 can also extend the functions of vitamin E by
regenerating it from its oxidized form. Tissue co-enzyme
Q10 levels are regulated through the mevalonate pathway,
increasing with various forms of oxidative stress, and
decreasing during aging. Related to its antioxidant properties,
co-enzyme Q10 is important for normal immune function.
This has been shown in a number of experimental and clinical
studies.
Healthy people have the ability to synthesize adequate
amounts of co-enzyme Q10. According to Dr. Karl Folkers
and other researchers, humans can synthesize co-enzyme Q10
from the amino acids tyrosine or phenylalanine and mevalonic
acid, all of which are abundant in the body. However, the
synthesis is a complex process involving 15 separate steps
which require many enzymes, nutritional mineral cofactors,
and vitamin coenzymes.
As a result, the biosynthesis of co-enzyme Q10 in the human
body requires a good diet – one that is high in vitamins,
minerals, and other nutrient factors. Yet, it has been shown
by NHANES I and II studies that many Americans do not
consume an adequate diet. Rather, for many, dietary intake
of water soluble vitamins, vitamin A, and some minerals and
trace elements is insufficient. Many of these nutrients are
essential for the biosynthesis of co-enzyme Q10. Thus, it is
not surprising that the nutritional status of co-enzyme Q10
tends to decline with advancing age. In addition, it has been
shown that in disease states, nutrients from food sources may
not be readily absorbed or bioavailable. According to Folkers
and other experts, co-enzyme Q10 should be considered an
essential nutrient, as it is well established that coenzyme Q10
is essential for the health of every cell in the human body.
INDICATIONS
RxLink Co-Enzyme Q10 softgels may be a useful dietary supplement
for those who wish to support their body’s own production of
co-enzyme Q10.
FORMULA (RxLink CoEnzyme Q10)
1 Softgel Capsule Contains:
Vitamin E ……………………………………………………….. 10 IU
(as d-alpha tocopherol)
Coenzyme Q 10 …………………………………………….. 100 mg
Other Ingredients: Capsules (gelatin, glycerin, water), rice
bran oil, lecithin, beeswax, zinc oxide, and annatto (color).
Contains soy. Manufactured on equipment that processes
peanuts. May contain traces of peanuts.
This product contains NO sugar, salt, dairy, yeast, wheat,
gluten, corn, preservatives, artificial colors, or flavors.
SUGGESTED USE
As a dietary supplement, adults take 1 softgel 1-3 times daily
with meals, or as directed by a healthcare professional.
SIDE EFFECTS
No adverse effects have been reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of
reach of children.
References on following page
REFERENCES
Alleva R, Tomasetti M, Battino M, Curatola G, Littarru GP, Folkers K. The
roles of coenzyme Q10 and vitamin E on the peroxidation of human low
density lipoprotein subfractions. Proc Natl Acad Sci USA 1995;92:9388-9391.
Amimoto T, Matsura T, Koyama S-Y, Nakanishi T, Yamada K, Kajiyama G.
Acetaminophen-induced hepatic injury in mice: The role of lipid peroxidation
and effects of pretreatment with coenzyme Q10 and a-tocopherol. Free Radic
Biol Med 1995;19:169-176.
Beyer RE. The role of ascorbate in antioxidant protection of biomembranes:
Interaction with vitamin E and coenzyme Q. J Bioenerg Biomembr
1994;26:349-358.
Bliznakov EG. Coenzyme Q, the immune system and aging. In: Biochemical
and Clinical Aspects of Coenzyme Q10, Vol 3, Folkers K and Yamamura Y
Eds., Elsevier Science Publishers, 1981, pp.331-326.
Chen H, Tappel AL. Vitamin E, selenium, trolox C, ascorbic acid palmitate,
acetylcysteine, coenzyme Q, b-carotene, canthaxanthin, and (+)-catechin
protect against oxidative damage to kidney, heart, lung and spleen. Free Radic
Res 1995;22:177-186.
Ernster L, Dallner G. Biochemical, physiological and medical aspects of
ubiquinone function. Biochim Biophys Acta Mol Basis Dis 1995;1271:195
204.
Folkers K, Littarru GP, Yamagami Y, Eds. Biochemical and Clinical Aspects
of Coenzyme Q10, Vol 6, Elsevier Science Publishers, 1991.
Folkers K, Morita M, McRee J, Jr. The activities of coenzyme Q10 and
vitamin B6 for immune responses. Biochem Biophys Res Commun
1993;193:88-92.
Folkers K, Simonsen R. Two successful double-blind trials with coenzyme
Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies.
Biochim Biophys Acta Mol Basis Dis 1995;1271:281-286.
Greenberg S, Frishman WH: Coenzyme Q10: a new drug for cardiovascular
disease. J Clin Pharm 1990;30:596-608.
Kamikawa T, Kobayashi A. Effects of coenzyme Q10 on exercise tolerance in
chronic stable angina pectoris. Am J Cardiol 1985;56:247-251.
Kontush A, Hübner C, Finckh B, Kohlschütter A, Beisiegel U. Antioxidative
activity of ubiquinol-10 at physiologic concentrations in human low density
lipoprotein. Biochim Biophys Acta Lipids Lipid Metab 1995;1258:177-187.
Langsjoen PH et al. Long-term safety and efficacy of coenzyme Q10 therapy
for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-523.
Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of
breast cancer with vitamin Q10 and the regression of metastases. Biochem
Biophys Res Commun 1995;212:172-177.
Maurer I et al. Coenzyme Q10 and respiratory chain enzyme activities
in hypertrophied human left ventricles with aortic stenosis. Am J Cardiol
1990;66:504-505.
Morita K, Ihnken K, Buckberg GD, Young HH. Studies of hypoxemic/
reoxygenation injury: Without aortic clamping. VII. Counteraction of oxidant
damage by exogenous antioxidants: Coenzyme Q10. J Thorac Cardiovasc
Surg 1995;110:1221-1227.
Mortensen SA et al. Deficiency of coenzyme Q10 in myocardial failure. Drugs
Exp Clin Res 1985;10:497-502.
Nakamura R et al. Study of CoQ10 enzymes in gingiva from patients with
periodontal disease and evidence for a deficiency of coenzyme Q10. Prc Natl
Acad Sci 1974;71:4156-4160.
Stoyanovsky DA, Osipov AN, Quinn PJ, Kagan VE. Ubiquinone dependent
recycling of vitamin E radicals by superoxide. Arch Biochem Biophys
1995;323:343-351..
These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Manufactured For:
RxLink Pharmaceuticals
Appleton, WI 54912 USA